Search on: PTEN PHOSPHOHYDROLASE 
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Descriptor English:   PTEN Phosphohydrolase 
Descriptor Spanish:   Fosfohidrolasa PTEN 
Descriptor Portuguese:   PTEN Fosfo-Hidrolase 
Synonyms English:   MMAC1 Protein
Mutated In Multiple Advanced Cancers 1 Protein
PTEN Phosphatase
PTEN Protein
PTEN Protein Phosphatase
Phosphatase and Tensin Homologue on Chromosome Ten Protein
Phosphatase, PTEN
Phosphatase, PTEN Protein
Phosphohydrolase, PTEN
Protein Phosphatase, PTEN  
Tree Number:   D08.811.277.352.650.850
D12.776.476.590
D12.776.624.776.695
Definition English:   A lipid phosphatase that contains a C2 DOMAIN and acts on phosphatidylinositol-3,4,5-trisphosphate to regulate various SIGNAL TRANSDUCTION PATHWAYS. It modulates CELL GROWTH PROCESSES; CELL MIGRATION; and APOPTOSIS. Mutations in PTEN are associated with COWDEN DISEASE and PROTEUS SYNDROME as well as NEOPLASTIC CELL TRANSFORMATION. 
History Note English:   2006(1997) 
Allowable Qualifiers English:  
AD administration & dosage AE adverse effects
AN analysis AI antagonists & inhibitors
BI biosynthesis BL blood
CF cerebrospinal fluid CS chemical synthesis
CH chemistry CL classification
DF deficiency DE drug effects
EC economics GE genetics
HI history IM immunology
IP isolation & purification ME metabolism
PK pharmacokinetics PD pharmacology
PH physiology PO poisoning
RE radiation effects ST standards
SD supply & distribution TU therapeutic use
TO toxicity UL ultrastructure
UR urine  
Record Number:   50580 
Unique Identifier:   D051059 

Occurrence in VHL: 		 

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